2011 Aug;79(8):453-66. doi: 10.1055/s-0031-1273397. Subsequent adequate trials with paroxetine and sertraline were ineffective. Response was defined as a 25% or greater reduction in the Y-BOCS score at study end and a Clinical Global Impression-Improvement scale rating of "much" or "very much" improved. This striking and unexpected effect was reproduced in a double-blind study at the National Institutes of Health in 2006. 1304, No. Enter your email address below and we will send you the reset instructions, If the address matches an existing account you will receive an email with instructions to reset your password, Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. [Efficacy of antipsychotic augmentation therapy in treatment-resistant obsessive-compulsive disorder: a meta-analysis of double-blind, randomised, placebo-controlled trials]. However, in a recent double-blind, placebo-controlled, study, memantine was not effective in the treatment of major depressive disorder (Zarate et al., 2006). Have anyone here tried memantine for pure o ocd ? Memantine is a glutamate receptor antagonist that has been reported to reduce Obsessive-Compulsive Disorder (OCD) symptoms in case studies of treatment-resistant individuals. Responders had significantly lower baseline Y-BOCS scores (2-tailed t tests, P < 0.05, t = 2.2) and had failed fewer SRIs (P