Takeaway Indomethacin can reduce severe pain from inflammatory and autoimmune conditions, such as rheumatoid arthritis, back pain, and chronic spine inflammation. Feeling Faint 3. See what others have said about , including the effectiveness, ease of use and side effects. Along with its needed effects, a medicine may cause some unwanted effects. Elevations of ALT or AST of 3 or more times the upper limit of normal have been reported in about 1% of patients in clinical trials with NSAIDs. Advertising revenue supports our not-for-profit mission. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. It can cause a reduction in urine that the fetus produces, and it can change the way the blood circulates through the fetus's body. NSAIDs cause an increased risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Some side effects may not be reported. Sections. Excessive Sweating 5. The most frequently reported adverse effects were nausea, headache, dizziness, vomiting, constipation, pruritus, diarrhea, dyspepsia, presyncope, rash, upper abdominal pain, somnolence, pruritus, hyperhidrosis, decreased appetite, hot flush, and syncope. These events can occur at any time during use and without warning symptoms. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Merck & Co, Inc, West Point, PA. 3. I have been taking this medication for a long time and I can report that the positive sides are much bigger than the side effects which I didn’t have. Read also: How to get rid of joint pain fast. Indomethacin is a nonsteroidal anti-inflammatory drug that reduces fever, pain and inflammation. The median time to reach peak concentrations (Tmax) was 1.67 hr and 2.02 hr for Tivorbex capsules and indomethacin IR capsules, respectively Food causes a significant decrease in the rate but not the overall extent of systemic absorption; 46% lower Cmax, 9% lower AUCinf, and 1.33 hr delayed Tmax (1.67 hr during fasted vs 3 hr during fed) Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to indomethacin: compounding powder, intravenous powder for injection, oral capsule, oral capsule extended release, oral suspension, rectal suppository, Very common (10% or more): Nausea (up to 34%), vomiting (up to 12%), Common (1% to 10%): Constipation, diarrhea, dyspepsia, upper abdominal pain, abdominal pain/distress, indigestion, heartburn, epigastric pain, gastrointestinal (GI) bleeding, gastrointestinal perforation, necrotizing enterocolitis, Uncommon (0.1% to 1%): Anorexia, bloating/distention, flatulence, peptic ulcer, gastroenteritis, rectal bleeding, proctitis, ulcerations/perforations/hemorrhage of the esophagus, stomach, duodenum, or small and large intestines, intestinal ulceration, stenosis, obstruction, development of ulcerative colitis, development of regional ileitis, ulcerative stomatitis, intestinal strictures, pancreatitis, Frequency not reported: Gastric perforation, gastritis, bleeding from sigmoid colon, perforation of existing sigmoid lesions, tenesmus, irritation of rectal mucosa, rectal burning/pain, rectal itching/discomfort, glossitis, esophageal lesions, tenesmus, Common (1% to 10%): GI bleeding, GI perforation, necrotizing enterocolitis, Frequency not reported: Gross/microscopic bleeding into gastrointestinal tract, vomiting, abdominal distention, transient ileus, gastric perforation, localized perforations of small/large intestines, melena[Ref]. Indomethacin is also used to treat pain in the shoulder caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint) and tendinitis (inflammation of the tissue that connects muscle to bone)… © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Can I take Tylenol while taking indomethacin and can these drugs be alternated every 3 hours? NSAIDs can also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Renal dysfunction has been reported in 41% of neonates and included at least 1 of the following: reduced urinary output, reduced urine sodium, chloride, or potassium; reduced urine osmolality, free water clearance, or GFR; elevated serum creatinine or BUN; or uremia. Itching 4. received an overall rating of 9 out of 10 stars from 25 reviews. Indomethacin is a medication that belongs to the class of non-steroidal anti-inflammatory drugs. [Ref], Uncommon (0.1% to 1%): Nephrotic syndrome, interstitial nephritis, elevated BUN, renal insufficiency, renal failure, Very common (10% or more): Renal dysfunction (41%), Frequency not reported: Elevated serum creatinine, renal failure, elevated BUN[Ref], Uncommon (0.1% to 1%): Hyperglycemia, hyperkalemia, glycosuria, weight gain, fluid retention, Common (1% to 10%): Hyponatremia, elevated serum potassium, Frequency not reported: Reduction in blood sugar/hypoglycemia, weight gain/fluid retention, metabolic acidosis, metabolic alkalosis[Ref], In a double blind placebo controlled trial of 405 premature infants weighing less than or equal to 1750 g with evidence of large ductal shunting, there was statistically significant greater incidence of bleeding problems, including gross or microscopic bleeding in GI tract, oozing from skin after needle stick, pulmonary hemorrhage, and disseminated intravascular coagulopathy in infants treated with this drug (n=206). Indomethacin side effects and drug information The indomethacin capsule drug is a kind of prescription drug in the market today. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Last updated on Sep 13, 2020. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Indocin SR (indomethacin) extended-release capsules is a nonsteroidal anti-inflammatory drug indicated for moderate to severe rheumatoid arthritis including acute flares of chronic disease, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, and acute painful shoulder (bursitis and/or tendinitis).What Are Side Effects of Indocin SR? In clinical trials, side effects that were reported in more than 3 percent of people taking indomethacin included heartburn or indigestion, headache, dizziness, and nausea (with or without vomiting). Copyright © 2021 IBM Watson Health. Common side effects of Indocin include nausea, vomiting, diarrhea, stomach discomfort, heartburn, rash, headache, dizziness and drowsiness. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at a greater risk for serious GI events. Indomethacin Side Effects, Contraindications, Rules of Use, and How It Work – Indometacin or indomethacin is a medication used to relieve mild to moderate pain. You may report them to the FDA. These side effects may go away during treatment as your body adjusts to the medicine. Methods: The hospital records of patients experiencing any postpartum complication between 1994 and 1999 were reviewed for adverse drug reactions (ADR) attributed to indomethacin. [Ref], Uncommon (0.1% to 1%): Leukopenia, bone marrow depression, anemia secondary to obvious or occult GI bleeding, aplastic anemia, hemolytic anemia, agranulocytosis, thrombocytopenic purpura, disseminated intravascular coagulation, Frequency not reported: Leukemia, blood dyscrasias/hematopoietic disorders, neutropenia, Frequency not reported: Disseminated intravascular coagulation, decreased platelet aggregation, thrombocytopenia[Ref], Very common (10% or more): Headache (up to 16%), dizziness (up to 15%), Common (1% to 10%): Presyncope, somnolence, syncope, intracranial bleeding, fainting, Uncommon (0.1% to 1%): Drowsiness, lightheadedness, paresthesia, aggravation of epilepsy and Parkinsonism, coma, peripheral neuropathy, convulsion, dysarthria, aseptic meningitis, optic neuritis, Very common (10% or more): Intraventricular hemorrhage (up to 14.3%), intracranial hemorrhage (up to 10.5%), Common (1% to 10%): Intracranial bleeding, periventricular leukomalacia[Ref], Common (1% to 10%): Depression, listlessness, Uncommon (0.1% to 1%): Anxiety, nervousness, insomnia, muzziness, psychic disturbances, psychotic episodes, mental confusion, depersonalization, Frequency not reported: Hallucinations[Ref], Uncommon (0.1% to 1%): Congestive heart failure, hypertension, hypotension, tachycardia, chest pain, arrhythmia, palpitations, angiitis, Frequency not reported: Thrombophlebitis, rapid fall in blood pressure resembling shock, cardiac failure, thrombotic events, Frequency not reported: Bradycardia, hypertension, cardiac failure[Ref], Common (1% to 10%): Pruritus, rash, sweating/hyperhidrosis, flushing, urticaria, Uncommon (0.1% to 1%): Petechiae, ecchymosis, exfoliative dermatitis, erythema nodosum, loss of hair/alopecia, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, angioedema, purpura, Frequency not reported: Fulminant necrotizing fasciitis, photosensitivity[Ref], Very rare (less than 0.01%): Allergy-induced vasculitis, Frequency not reported: Hypersensitivity reactions, Frequency not reported: Hypersensitivity reactions[Ref], Uncommon (0.1% to 1%): Corneal deposits, retinal disturbances, blurred vision, diplopia, Frequency not reported: Orbital/periorbital pain, double vision, Very common (10% or more): Retinopathy of prematurity (up to 21.1%), Common (1% to 10%): Retrolental fibroplasia, Very common (10% or more): Post-procedural edema (up to 26%), post-procedural hemorrhage (up to 11%), Common (1% to 10%): Post-procedural swelling, vertigo, fatigue, malaise, tinnitus, asthenia, exhaustion, Uncommon (0.1% to 1%): Hearing disturbances, deafness, edema, fever, Postmarketing reports: Exacerbation of infection, Frequency not reported: Exacerbation of infection, edema[Ref]. CAS ID 53-86-1 Trade Name Indocid, Indocin Metabolism Hepatic… NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. O 0. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. This risk may occur early in treatment and may increase with duration of use. Other potential side effects include: Indomethacin has two potentially serious side effects for the fetus. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in … Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Indomethacin is also tagged as a generic medicine. This content does not have an English version. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. Generally, indomethacin is used to address the symptoms of swelling and joint pain in osteoarthritis or rheumatoid arthritis. This risk may occur early in treatment and may increase with duration of use. Common side effects include drug hypersensitivity among females and drug ineffective among males. We comply with the HONcode standard for trustworthy health information -. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. These events can occur at any time during use and without warning symptoms. aspirin, prednisone, acetaminophen, tramadol, ibuprofen, meloxicam, cyclobenzaprine, duloxetine, Tylenol, naproxen. Indomethacin and gout are something you have experienced at some point and something you will experience in the future, sadly. Indomethacin is contraindicated in the setting of CABG surgery. All rights reserved. It has several side effects, of which gastrointestinal and cardiovascular side effects are more common. Latest on COVID-19 vaccination by site: Abdominal or stomach cramping, burning, or tenderness, blistering, peeling, or loosening of the skin, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, coughing that sometimes produces a pink frothy sputum, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position, greatly decreased frequency of urination or amount of urine, jerky movements of the head, face, mouth, and neck, large, flat, blue or purplish patches in the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, muscle spasm or jerking of all extremities, numbness or tingling in the hands, feet, or lips, pain or discomfort in the upper stomach or throat, painful, red lumps under the skin, mostly on the legs, persistent bleeding or oozing from puncture sites, mouth, or nose, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness of the face, neck, arms and occasionally, upper chest, seeing, hearing, or feeling things that are not there, slow, fast, irregular, pounding, or racing heartbeat or pulse, sores, ulcers, or white spots on the lips or tongue or inside the mouth, swelling of the breasts or breast soreness in both females and males, swelling of the face, fingers, feet, ankles, or lower legs, trembling and shaking of the fingers and hands, vomiting of blood or material that looks like coffee grounds, weakness in the arms, hands, legs, or feet, Confusion about identity, place, and time, unusual drowsiness, dullness, or feeling of sluggishness, Continuing ringing or buzzing or other unexplained noise in the ears, difficulty having a bowel movement (stool), changes in patterns and rhythms of speech, excess air or gas in the stomach or intestines, feeling of constant movement of self or surroundings. Rare cases of severe hepatic reactions, including jaundice, fatal fulminant hepatitis, liver necrosis, and hepatic failure, some with fatal outcomes, have been reported. Indomethacin blocks the enzymes that … Drug information provided by: IBM Micromedex. Commonly reported side effects of indomethacin include: headache. Indomethacin is a non-steroidal anti-inflammatory that is one of the most common drugs for dealing with a acute gout attacks. Drug class: Nonsteroidal anti-inflammatory drugs, Abdominal or stomach cramping, burning, or tenderness, blistering, peeling, or loosening of the skin, coughing that sometimes produces a pink frothy sputum, greatly decreased frequency of urination or amount of urine, jerky movements of the head, face, mouth, and neck, large, flat, blue or purplish patches in the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, muscle spasm or jerking of all extremities, numbness or tingling in the hands, feet, or lips, pain or discomfort in the upper stomach or throat, painful, red lumps under the skin, mostly on the legs, persistent bleeding or oozing from puncture sites, mouth, or nose, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness of the face, neck, arms and occasionally, upper chest, seeing, hearing, or feeling things that are not there, slow, fast, irregular, pounding, or racing heartbeat or pulse, sores, ulcers, or white spots on the lips or tongue or inside the mouth, swelling of the breasts or breast soreness in both females and males, swelling of the face, fingers, feet, ankles, or lower legs, trembling and shaking of the fingers and hands, vomiting of blood or material that looks like coffee grounds, weakness in the arms, hands, legs, or feet, Confusion about identity, place, and time, unusual drowsiness, dullness, or feeling of sluggishness, Continuing ringing or buzzing or other unexplained noise in the ears, difficulty having a bowel movement (stool), changes in patterns and rhythms of speech, excess air or gas in the stomach or intestines, feeling of constant movement of self or surroundings. While it is effective at relieving the symptoms of gout from many people, it is also known for side effects such as gastritis, liver & … Indomethacin may cause central nervous system (CNS) side effects and should be used with caution in patients with a seizure disorder, Parkinson's disease, or depression or other psychiatric disturbance. Diarrhea 3. It's available only as oral liquid drugs and can serve as rectal-suppository medication. Applies to indomethacin: oral capsule, oral capsule extended release, oral suspension. Constipation 2. Tell your doctor if you have any side effect that bothers you or that does not go away. Buy Indomethacin 25 mg Tablet Online. Indomethacin has several adverse effects, the most common of which is renal failure. Commonly reported side effects of indomethacin include: headache. Mayo Clinic does not endorse companies or products. Why is my poop green? Information from various medical literature states that 44% of infants treated with this drug had oliguria. All rights reserved. These elevations may progress, remain unchanged, or may be transient with continued treatment. It is used to reduce swelling and to treat pain.It may be used for painful joint and muscular problems such as arthritis, tendinitis, bursitis, and gout. She has spent the last 10 years working for an internationally recognized medical facility where she found her passion for making complicated topics easier to … Indomethacin (Oral Route) Print. What are the possible side effects of indomethacin (Indocin, Indocin SR, Tivorbex)? Side effects are reported by people who take Indomethacin. See below for a comprehensive list of adverse effects. Indomethacin may aggravate these conditions. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Along with its needed effects, indomethacin may cause some unwanted effects. [Ref], Uncommon (0.1% to 1%): Hematuria, vaginal bleeding, proteinuria, breast enlargement/tenderness, gynecomastia, Frequency not reported: Urinary frequency, Very common (10% or more): Oliguria (44%), Frequency not reported: Transient oliguria[Ref], Frequency not reported: Bleeding/oozing from skin following needle puncture[Ref], Uncommon (0.1% to 1%): Muscle weakness, involuntary muscle movements, Frequency not reported: Hypercreatininemia, acceleration of cartilage degeneration[Ref], Uncommon (0.1% to 1%): Dyspnea, acute respiratory distress, asthma, pulmonary edema, epistaxis, Frequency not reported: Bronchospasm, pulmonary eosinophilia, alveolitis, Frequency not reported: Pulmonary hemorrhage, pneumothorax, pulmonary hypertension, apnea, exacerbation of preexisting pulmonary infection[Ref], 1. Loss Of Appetite 6. Stomach Or Intestinal Ulcer If experienced, these tend to have a Less Severe expression 1. Indomethacin is an anti-inflammatory medication, that belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). 2. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Elderly patients are at greater risk for serious gastrointestinal events. It is also used to relieve mild to moderate pain associated with a headache, toothache, muscle pain, or back pain. There was no statistically significant difference between treatment groups of intracranial hemorrhage. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. Pediatric patients: There have been cases of hepatotoxicity, including fatalities, in pediatric patients with juvenile rheumatoid arthritis. It is similar to ibuprofen and naproxen (Naprosyn, Aleve).Indomethacin works by reducing the production of prostaglandins. This risk may occur early in treatment and may increase with duration of use. Indomethacin prescription and dosage sizes information for physicians and healthcare professionals. [Ref], Uncommon (0.1% to 1%): Toxic hepatitis, jaundice, elevated ALT/AST, Frequency not reported: Cholestasis, abnormal liver function[Ref], In controlled clinical trials, renal dysfunction occurred statistically significantly more frequently during IV use in neonates than in those treated with placebo. Temporary Redness Of Face And Neck 8. Indomethacin is contraindicated in the setting of CABG surgery. Indomethacin causes indigestion in many women. Call your doctor for medical advice about side effects. NSAIDs can also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Cerner Multum, Inc. "UK Summary of Product Characteristics." Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Discontinue … Drowsiness 4. Other side effects of indomethacin can include fatigue, diarrhea, and abdominal pain. "Product Information. Indomethacin can cause mild or serious side effects. See below for a comprehensive list of adverse effects. Side effects of indomethacin injection in infants are uncommon, but may include: bleeding; coagulation problems; renal failure . , oral capsule extended release, oral capsule extended release, oral.... Works by reducing the production of prostaglandins stroke, which can be fatal reactions, warnings and side of. We comply with the HONcode standard for trustworthy health information - used to relieve mild to moderate pain with. And inflammation identify pills, check interactions and set up your own personal medication records joint. Use ; Precautions ; side effects that may occur, if they do occur they may need medical.... An overall rating of 9 out of 10 stars from 25 reviews are... And patients with a headache, dizziness and drowsiness acute gout attacks notice any other effects a! Of joint pain fast the most common drugs for dealing with a gout. Effects are more common There was no statistically significant difference between treatment groups of intracranial hemorrhage SR, Tivorbex?... Swelling and joint pain fast from various medical literature states that 44 % of infants treated this. May progress, remain unchanged, or back pain if they do occur they may need medical.!, including the effectiveness, ease of use adverse reactions, warnings and side.... Merck & Co, Inc, West Point, PA. 3 with abdominal pain of CABG surgery check these... And may increase with duration of use works by reducing the production of prostaglandins diarrhea or constipation together with pain! Non-Steroidal anti-inflammatory that is one of the key side effects of indomethacin can reduce Severe pain from and... Can be fatal information the indomethacin capsule drug is a nonsteroidal anti-inflammatory drug that reduces fever, pain inflammation!: headache but may include: dizziness, dyspepsia, hyponatremia, and is updated...., meloxicam, cyclobenzaprine, duloxetine, Tylenol, naproxen, remain unchanged, may. Medical Education and Research ( MFMER ) while taking indomethacin adjusts to the medicine ( Naprosyn, Aleve.Indomethacin... We comply with the HONcode standard for trustworthy health information - up your own personal medication records it has side! That … side effects and drug information, identify pills, check interactions and set up your personal! Occur they may need medical attention treated with this drug had oliguria in treatment may..., these tend to have a Less Severe expression 1 may increase with duration of.! What is Indocin SR, if they do occur they may need medical attention reduce pain... Prostaglandins are chemicals that the body produces and which cause the fever and pain are! The phase IV clinical study is indomethacin side effects by eHealthMe based on 11,123 reports from the FDA, and spine... Of infants treated with this drug had oliguria for a comprehensive list adverse! Of 1 or more liver function tests can occur in up to 15 % of infants with. From 25 reviews, pain and inflammation Writer with a acute gout attacks, redistributed or otherwise used commercial! To be dose related ; renal function usually returns to normal 24 hours following.... Early in treatment and may increase with duration of use ).Indomethacin works by the... Include nausea, vomiting, diarrhea, stomach discomfort, heartburn,,! Conditions and Privacy Policy linked below healthcare provider to ensure the information displayed on this page applies to indomethacin oral. If experienced, these tend to have a Less Severe expression 1 the indomethacin capsule drug is a medication belongs., which can be fatal NSAIDs ) to relieve mild to moderate pain with! To relieve mild to moderate pain associated with inflammation to other similar.. Of 9 out of 10 stars from 25 reviews drug hypersensitivity among females and drug among... For commercial purposes medication, that belongs to the medicine be able to you... Prostaglandins are chemicals that the body produces and which cause the fever and pain that are associated a... Indomethacin may cause some unwanted effects of CABG surgery Proper use ; Precautions ; side ;..., dyspepsia, hyponatremia, and nausea over-the-counter medicines and natural Products, West Point, PA. 3 CABG.. Treatment groups of intracranial hemorrhage rash, headache, dizziness and drowsiness elderly patients and patients with a acute attacks. This effect may be able to tell you about ways to prevent or reduce some of the key effects. Dosage sizes information for physicians and healthcare professionals trustworthy health information: verify here from 25 reviews medical. Drug is a kind of prescription drug in the market today problems ; function... Relieve mild to moderate pain associated with inflammation newsletters from Mayo Clinic list contains some of side... What is Indocin SR, Tivorbex )? complies with the HONcode standard for trustworthy health information verify... The medication may cause diarrhea or constipation together with abdominal pain every 3?! Iv clinical study is created by eHealthMe based on 11,123 reports from the FDA, and.!